abstract：BACKGROUND/AIM:Variations in cell phenotype in a single-cell-derived clone may result from asymmetric cell divisions that lead to different cell fate in a homogenous microenvironment. The aim of this study was to demonstrate the extent of cell variety in single-cell-derived clones and propose a different strategy in tr...

journal_title：Anticancer research

authors： Khan GN,Kim EJ,Shin TS,Lee SH

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:NSC697923, a ubiquitin-conjugating enzyme E2 (UBE2) inhibitor, was suggested as an agent to degrade hypoxia-inducible factor 1 alpha subunit (HIF1α), a key factor in radiation resistance. We attempted to clarify whether NSC697923 could overcome radiation resistance. MATERIALS AND METHODS:Radiation resistanc...

journal_title：Anticancer research

authors： Gombodorj N,Yokobori T,Yoshiyama S,Kawabata-Iwakawa R,Rokudai S,Horikoshi I,Nishiyama M,Nakano T

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Pleomorphic rhabdomyosarcomas of the uterus, mainly occurring in postmenopausal women with leading symptoms of vaginal bleeding and abdominal pain, are very rare malignant tumors of the female genital tract. Due to the inefficiency of the adjuvant therapy, the outcome remains poor in the majority of the repo...

journal_title：Anticancer research

authors： Alavi S,Eckes L,Kratschell R,Taube ET,Rosseck F,Wieners G,Sehouli J

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIM:Primary Non-Hodgkin's lymphoma of the gallbladder (PNHL-GB) is extremely rare and data on clinical characteristics, optimal management and outcomes of these patients are limited to anecdotal reporting. We, therefore, sought to examine these patients using a population-based database. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Ayub A,Rehmani S,Al-Ayoubi AM,Lewis E,Santana-Rodríguez N,Raad W,Bhora F,Kim G

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the fifth most common cancer in Africa, with significant differences in incidence, biology and clinical behavior from other populations. MATERIALS AND METHODS:We studied prevalence and clinicopathological features of microsatellite instability (MSI) and young onset CRC in 83 archi...

journal_title：Anticancer research

authors： Irabor DO,Oluwasola OA,Ogunbiyi OJ,Ogun OG,Okolo CA,Melas M,Gruber SB,Shi C,Raskin L

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Taxane-based chemotherapy is useful for peritoneal dissemination control in advanced/recurrent gastric cancer; however, insufficient relative dose intensity (RDI) may preclude disease control achievement. Nab-paclitaxel, with high tumour permeability, is a promising second- or later-line treatment. PATIENTS...

journal_title：Anticancer research

authors： Kanazawa Y,Fujita I,Kakinuma D,Arai H,Matsuno K,Shimoda T,Ko K,Kato S,Uchida E

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIM:The transcription factor Y-box-binding protein 1 (YB1) is overexpressed in many types of human cancers. YB1 regulates the G1 phase of the cell cycle by controlling transcription of G1 regulators. Here, we report that YB1 is also involved in regulating G2/M phase. MATERIALS AND METHODS:YB1-depleted TKO c...

journal_title：Anticancer research

authors： Kotake Y,Arikawa N,Tahara K,Maru H,Naemura M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND/AIM:Ninjurin1 is a 17-kDa membrane protein that is highly expressed in circulating tumor cells (CTCs) obtained from locally-advanced prostate cancer patients. As CTCs are implicated in the initiation of distant metastasis, we examined the potential contribution of Ninjurin1 to the motility of prostate cancer...

journal_title：Anticancer research

authors： Park J,Joung JY,Hwang JE,Hong D,Park WS,Lee SJ,Lee KH

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND/AIM:Lung cancer is the first cause of cancer related deaths in both males and females. Epithelial-mesenchymal transition (EMT) is a reversible process by which epithelial cells transform to mesenchymal stem cells by losing their cell polarity and cell-to-cell adhesion, gaining migratory and invasive properti...

journal_title：Anticancer research

authors： Tsoukalas N,Aravantinou-Fatorou E,Tolia M,Giaginis C,Galanopoulos M,Kiakou M,Kostakis ID,Dana E,Vamvakaris I,Korogiannos A,Tsiambas E,Salemis N,Kyrgias G,Karameris A,Theocharis S

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND/AIM:Elderly patients with HPV+ oropharyngeal cancer (OPC) represent an understudied cohort of the HPV epidemic. We aimed to investigate the clinical presentation, treatment tolerability and outcomes in patient's ≥65 years old with HPV+ OPC. PATIENTS AND METHODS:We identified all patients aged 65 and older t...

journal_title：Anticancer research

authors： Dave E,Su W,Gupta V,Miles B,Demicco E,Soriano T,Bakst RL

更新日期：2017-04-01 00:00:00

abstract：:We herein report a case of locally advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer that achieved a pathological complete response (pCR) with pertuzumab, trastuzumab and docetaxel therapy. A 70-year-old female presented with an elastic hard mass, 5.0 cm in diameter with broad redness and...

journal_title：Anticancer research

authors： Inoue Y,Yamashita N,Tokunaga E,Tanaka K,Ueo H,Saeki H,Oki E,Yamamoto H,Maehara Y

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The aim of this retrospective study was to evaluate the clinical relevance of serum p53 antibody (S-p53Ab) as a biomarker and to investigate whether its diagnostic value could be improved when combined with other biomarkers of gastric cancer (GC). PATIENTS AND METHODS:Serum samples were obtained preoperativ...

journal_title：Anticancer research

authors： Kunizaki M,Fukuda A,Wakata K,Tominaga T,Nonaka T,Miyazaki T,Matsumoto K,Sumida Y,Hidaka S,Yasutake T,Sawai T,Hamamoto R,Nanashima A,Nagayasu T

更新日期：2017-04-01 00:00:00

abstract：AIM:To report the outcomes of salvage robot-assisted radical prostatectomy (S-RaRP). PATIENTS AND METHODS:Fourteen patients underwent S-RaRP. The mean initial prostatic-specific antigen level was 14.3 ng/ml and mean Gleason score was 6.93. Initial definitive treatment was external irradiation in 11 cases, cyberknife i...

journal_title：Anticancer research

authors： Ou YC,Hung SC,Hwang LH,Yang CK,Hung SW,Tung MC

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND/AIM:We have previously reported that doxorubicin (DXR) showed much higher cytotoxicity against human oral squamous cell carcinoma cell lines compared to normal human mesenchymal normal oral cells (gingival fibroblast, periodontal ligament fibroblast, pulp cell), yielding high tumor-specificity. However, we u...

journal_title：Anticancer research

authors： Sakagami H,Okudaira N,Masuda Y,Amano O,Yokose S,Kanda Y,Suguro M,Natori T,Oizumi H,Oizumi T

更新日期：2017-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most aggressive intracranial tumor characterized with infaust prognosis. Despite advances in neurosurgical and radiotherapeutic techniques and chemotherapy, the median overall survival ranges between 12-15 months from diagnosis. The main cause of treatment failure is considered the...

journal_title：Anticancer research

authors： Ondracek J,Fadrus P,Sana J,Besse A,Loja T,Vecera M,Radova L,Smrcka M,Slampa P,Slaby O

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIM:Previous genetic and morphologic characterisation of mucinous tubular and spindle cell carcinoma (MTSCC) have yielded controversial results. The aim of this study was to explain the phenotypic heterogeneity of MTSCC diagnosed by genetic means. MATERIALS AND METHODS:We analyzed 7 MTSCC by array CGH and m...

journal_title：Anticancer research

authors： Banyai D,Vastag F,Yusenko M,Bugert P,Kovacs G

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:It has been suggested that prognosis in familial breast cancer could be influenced by the parent of origin, with a worse prognosis when inherited paternally. This study aimed to investigate the effect of the parent of origin on prognosis. PATIENTS AND METHODS:Index patients were divided into two study group...

journal_title：Anticancer research

authors： Wendt C,Lindblom A,Arver B,VON Wachenfeldt A,Margolin S

更新日期：2017-03-01 00:00:00

abstract：AIM:To identify predictors of poor prognosis of patients with colon cancer (CC) who underwent surgery with curative intent, we investigated the association between the albumin to globulin ratio (AGR) with clinicopathological findings such as overall (OS) and disease-free (DFS) survival. PATIENTS AND METHODS:We conduct...

journal_title：Anticancer research

authors： Fujikawa H,Toiyama Y,Inoue Y,Imaoka H,Shimura T,Okigami M,Yasuda H,Hiro J,Yoshiyama S,Saigusa S,Kobayashi M,Ohi M,Araki T,Mohri Y,Kusunoki M

更新日期：2017-03-01 00:00:00

abstract：AIM:To assess outcomes in patients treated with first-line bevacizumab-containing therapy for human epidermal growth factor receptor (HER)2-negative metastatic breast cancer (mBC) at a single centre with a homogenous standard-of-care. PATIENTS AND METHODS:Information on patient and disease characteristics, efficacy, a...

journal_title：Anticancer research

authors： Dieras V,Pop S,Berger F,Dujaric ME,Beuzeboc P,Escalup L,Bidard FC,Cottu PH,LE Tourneau C,Piperno-Neumann S,Laurence V,Robain M,Asselain B,Pierga JY

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIM:To evaluate the effectiveness of enzalutamide in Italian patients with hormone-refractory metastatic castration-resistant prostate cancer, progressing after chemotherapy with docetaxel plus prednisone. PATIENTS AND METHODS:A total of 60 patients were enrolled. Reduction in serum prostate-specific antige...

journal_title：Anticancer research

authors： Cicero G,DE Luca R,Dorangricchia P,Dieli F

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIM:Only 0.1-0.17% of all lung cancer patients are diagnosed with stage I or II small cell lung cancer (SCLC). Radiochemotherapy remains the standard treatment for limited stage disease. This study focused on prognostic factors in early stage SCLC treated with radiochemotherapy. PATIENTS AND METHODS:Seven f...

journal_title：Anticancer research

authors： Käsmann L,Bolm L,Janssen S,Rades D

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND/AIM:Combining an anticancer agent fenretinide (HPR) or C6-pyridinium ceramide (LCL29) with Foscan-mediated photodynamic therapy (FoscanPDT) is expected to augment anticancer benefits of each substance. We showed that treatment with FoscanPDT+HPR enhanced accumulation of C16-dihydroceramide, and that fumonisi...

journal_title：Anticancer research

authors： Boppana NB,Kraveka JM,Rahmaniyan M,Li LI,Bielawska A,Bielawski J,Pierce JS,Delor JS,Zhang K,Korbelik M,Separovic D

更新日期：2017-02-01 00:00:00

abstract：:Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been indicated as a novel cancer drug target, since it plays an important role in diverse oncogenic processes including survival, cell proliferation and migration. Emerging STAT3 inhibitors have demonstrated efficacy in cancer ce...

journal_title：Anticancer research

authors： Tian J,Xiao H,Wu R,Cao Y,Li C,Xu R,Pierson CR,Finlay JL,Yang F,Gu N,Lin J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:CD98 expression is high in various human neoplasms. However, the relationship of CD98 expression with the clinicopathological factors of gastric cancer (GC) remains unclear. This study examined CD98 expression and its clinicopathological impact on GC. PATIENTS AND METHODS:Three hundred and thirty-one patien...

journal_title：Anticancer research

authors： Satoh T,Kaira K,Takahashi K,Takahashi N,Kanai Y,Asao T,Horiguchi J,Oyama T

更新日期：2017-02-01 00:00:00

abstract：:Mutations affecting the mechanistic target of rapamycin (MTOR) signalling pathway are frequent in human cancer and have been identified in up to 15% of pancreatic neuroendocrine tumours (NETs). Grade A evidence supports the efficacy of MTOR inhibition with everolimus in pancreatic NETs. Although a significant proporti...

journal_title：Anticancer research

authors： Backman S,Norlén O,Eriksson B,Skogseid B,Stålberg P,Crona J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND/AIM:RASA1 (p120RasGAP), encodes Ras GTPase-activating protein 1 and, is a potent tumor suppressor gene that is frequently inactivated in several human cancer types. However, its precise role in hepatocellular carcinoma (HCC) has been blurred. MATERIALS AND METHODS:We hypothesized that RASA1 plays a crucial ...

journal_title：Anticancer research

authors： Chen YL,Huang WC,Yao HL,Chen PM,Lin PY,Feng FY,Chu PY

更新日期：2017-02-01 00:00:00

abstract：:The aim of this study was to evaluate the possible role in and contribution of antioxidant enzymes to bladder cancer (BC) etiology and recurrence after transurethral resection (TUR). We enrolled 40 patients with BC who underwent TUR and 100 sex- and age-matched healthy controls. The analysis was performed at diagnosis...

journal_title：Anticancer research

authors： Wieczorek E,Jablonowski Z,Tomasik B,Gromadzinska J,Jablonska E,Konecki T,Fendler W,Sosnowski M,Wasowicz W,Reszka E

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND/AIM:To assess prognosis of women aged 75 and older according to breast cancer (BC) diagnosis circumstances. PATIENTS AND METHODS:A retrospective cohort study was conducted in the Amiens, France, regional oncologic referral center between 2005 and 2015. Two groups were formed depending on whether the patient...

journal_title：Anticancer research

authors： Ilenko A,Sergent F,Mercuzot A,Zitoun M,Chauffert B,Foulon A,Gondry J,Chevreau J

更新日期：2017-02-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) represents the most malignant primary brain tumor in adults with generally dismal prognosis, early clinical deterioration and high mortality. GBM is extremely invasive, characterized by intense and aberrant vascularization and high resistance to multimodal treatment. Standard therapy (sur...

journal_title：Anticancer research

authors： Polivka J Jr,Polivka J,Holubec L,Kubikova T,Priban V,Hes O,Pivovarcikova K,Treskova I

更新日期：2017-01-01 00:00:00

abstract：AIM:To investigate the possibility of enhancing an anti-metastatic effect of 5-fluorouracil (5-FU) on colorectal cancer (CRC) cells by combining it with continuous calcium supplementation. MATERIALS AND METHODS:Optimal doses of 5-FU with/without lactate salt (CaLa) were determined via clonogenicity and 3-(4,5-dimethyl...

journal_title：Anticancer research

authors： Park M,Sundaramoorthy P,Sim JJ,Jeong KY,Kim HM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:F-Box protein 45 (FBXO45) is reported to be associated with cancer aggressiveness. We investigated the relationship between FBXO45 and clinicopathological factors in gastric cancer (GC). MATERIALS AND METHODS:We used immunohistochemistry to investigate FBXO45 expression in 104 GC samples; the prognostic val...

journal_title：Anticancer research

authors： Kogure N,Yokobori T,Ogata K,Altan B,Mochiki E,Ohno T,Toyomasu Y,Yanai M,Kimura A,Yanoma T,Suzuki M,Bai T,Asao T,Kuwano H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Sunitinib is a tyrosine kinase inhibitor (TKI) targeting tumour angiogenesis in patients with advanced renal cell carcinoma (RCC). Currently no universally agreed model exists correlating the expression of angiogenesis markers with the success of treatment. PATIENTS AND METHODS:We retrospectively analysed a...

journal_title：Anticancer research

authors： Stubbs C,Bardoli AD,Afshar M,Pirrie S,Miscoria M,Wheeley I,Porfiri E

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIM:To investigate whether high-dose-rate (HDR) intracavitary brachytherapy (IBT) dose ratios can predict treatment outcomes in patients with stage IIB cervical cancer. PATIENTS AND METHODS:Ninety-three patients treated with weekly cisplatin-based concurrent chemoradiotherapy and HDR IBT were analyzed. Pote...

journal_title：Anticancer research

authors： Cho O,Noh OK,Oh YT,Chang SJ,Chun M

更新日期：2017-01-01 00:00:00

abstract：:The multifaceted involvement of the active vitamin D metabolite 1,25-dihydroxyvitamin D3 (henceforth referred to by the synonyms 1,25(OH)2D3, calcitriol or vitamin D) in blunting the growth of cancer cells is amply recognized. In this review we focused our attention on the cross-talk between 1,25 (OH)2D3 and the tumor...

journal_title：Anticancer research

authors： Shany S,Sigal-Batikoff I,Lamprecht S

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Isothiocyanates are constituents of cruciferous vegetables which have been associated with reduced cancer risk partially through their ability to induce apoptosis in malignant cells including melanoma. MATERIALS AND METHODS:We have utilized human malignant melanoma (A375), epidermoid carcinoma (A431) and im...

journal_title：Anticancer research

authors： Mantso T,Sfakianos AP,Atkinson A,Anestopoulos I,Mitsiogianni M,Botaitis S,Perente S,Simopoulos C,Vasileiadis S,Franco R,Pappa A,Panayiotidis MI

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) is considered to be an oncogene in many cancer types. However, the role of DANCR in diagnosis and progression of hepatocellular carcinoma (HCC) is still unknown. PATIENTS AND METHODS:In this study, 146 participants including hea...

journal_title：Anticancer research

authors： Ma X,Wang X,Yang C,Wang Z,Han B,Wu L,Zhuang L

更新日期：2016-12-01 00:00:00

abstract：AIM:The aim of this study was to evaluate the detection rate of bone metastases and the added value of 11C-acetate (ACE) positron-emission tomography/computed tomography (PET/CT) compared to bone scintigraphy (BS) in high-risk prostate cancer (PC). MATERIALS AND METHODS:A total of 66 untreated patients with high-risk ...

journal_title：Anticancer research

authors： Strandberg S,Karlsson CT,Ogren M,Axelsson J,Riklund K

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Our aim was to analyze the impact of intraperitoneal chemotherapy (IPC), administered with direct peritoneal puncture, on the survival of patients with pretreated ovarian cancer in a real-life setting. PATIENTS AND METHODS:This was a retrospective study comparing patients with advanced ovarian cancer treate...

journal_title：Anticancer research

authors： Nicoletto MO,Casarin A,Baldoni A,Rulli E,Tasca G,Baretta Z,Artioli G,Lombardi G,Cappetta A,Floriani I,Randon G,Valpione S,Litta P,Conte P,Mocellin S,Aliberti C

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND/AIM:To validate the melanoma nomogram and improve its function in prediction of nodal dissemination by incorporating a molecular marker in the model. Microphthalmia transcription factor (MITF) is an important regulator of melanocyte homeostasis and differentiation. We have shown that the grade of MITF expres...

journal_title：Anticancer research

authors： Naffouje SA,Naffouje R,Chen J,Salti GI

更新日期：2016-12-01 00:00:00

abstract：AIM:To estimate the clinical outcomes of induction chemotherapy (IC) followed by standard chemoradiotherapy (CRT) and CRT alone in patients with locally advanced human papilloma virus (HPV)-negative oropharyngeal squamous cell carcinoma. PATIENTS AND METHODS:Consecutive patients with histologically-proven HPV-negative...

journal_title：Anticancer research

authors： DE Felice F,Abate G,Galdieri A,Bulzonetti N,Musio D,Tombolini V

更新日期：2016-12-01 00:00:00